Transglutaminases edited By Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus

Full Title: Transglutaminases: Multiple Functional Modifiers And Targets For New Drug Discovery
Author/Editor(s): Kiyotaka Hitomi; Soichi Kojima; Laszlo Fesus
ISBN: 443155825X, 9784431558255
Publisher: Springer
Published/Copyright Year: 2016
Language: English
Physical Description: online resource included,
Edition: 1st Edition 2015. [View All Editions]
Number of pages: 391 (VIII, 391 pages 85 Illustrationsus., 37 Illustrationsus. in color)
Categories:
Medicine
Pharmaceutical Technology
Biochemistry
Enzymology
Biomedicine
Pharmaceutical Sciences/Technology
Animal Biochemistry


Content:
1 Structure of Transglutaminases. Unique Features Serve Diverse Functions
2 Control of Tg Functions Depending on their Localization
3 Preferred Substrate Structure of Transglutaminases
4 Insights into Transglutaminase 2 Function Gained from Genetically-Modified Animal Models
5 Tranglutaminase in Invertebrates
6 Formation of Integrin-Binding Site on Polymer of Transglutamination
7 Transglutaminase 2-Mediated Gene Regulation
8 The Role of Transglutaminase Type 2 in the Regulation of Autophagy
9 Transglutaminase 2 and Celiac Disease
10 Transglutaminase ii and Metastasis: How Hot is the Link- 11 Transglutaminases: Expression in Kidney and Relation to Kidney Fibrosis
12 Transglutaminases in Bone Formation and Bone Matrix Stabilization
13 Transglutaminases and Neurological Diseases
14 Transglutaminase; Mechanism by Oxidative Stress
15 Blood Coagulation Factor Xiii : A Multifunctional Transglutaminase
16 Inhibition of Transglutaminase
17 Substrate Engineering of Microbial Transglutaminase for Site-Specific Protein Modification and Bioconjugation.
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community. .

Electronic Resources:
http://dx.doi.org/10.1007/978-4-431-55825-5

ISBNPlus ID: SPR.VC1.183653-11-6771856
Form: Nonfiction
LC Call No: RS380
Dewey Decimal: 615.19
Released Date: 20160205

Download BiBTeX of this book (.bib)
@book{isbnplus9784431558255,
 title={Transglutaminases: Multiple Functional Modifiers And Targets For New Drug Discovery},
 author={Kiyotaka Hitomi and Soichi Kojima and Laszlo Fesus},
 isbn={9784431558255},
 url={http://isbnplus.org/9784431558255},
 year={2016},
 publisher={Springer}
}
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%0 Book
%T Transglutaminases: Multiple Functional Modifiers And Targets For New Drug Discovery
%A Kiyotaka Hitomi
%A Soichi Kojima
%A Laszlo Fesus
%@ 9784431558255
%U http://isbnplus.org/9784431558255
%D 2016
%I Springer
Download 9784431558255.enw
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TY  - BOOK
T1  - Transglutaminases: Multiple Functional Modifiers And Targets For New Drug Discovery
A1  - Kiyotaka Hitomi
A1  - Soichi Kojima
A1  - Laszlo Fesus
SN  - 9784431558255
UR  - http://isbnplus.org/9784431558255
Y1  - 2016
PB  - Springer
ER  - 
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APA Style:
Hitomi, K., Kojima, S. & Fesus, L. (2016). Transglutaminases: Multiple Functional Modifiers And Targets For New Drug Discovery. : Springer.

MLA Style:
Hitomi, Kiyotaka, Soichi Kojima, and Laszlo Fesus. Transglutaminases: Multiple Functional Modifiers And Targets For New Drug Discovery. : Springer, 2016. Print.

Chicago Style:
Hitomi, Kiyotaka, Soichi Kojima, and Laszlo Fesus. Transglutaminases: Multiple Functional Modifiers And Targets For New Drug Discovery. : Springer, 2016.